Also called Blue-Grey syndrome.
Occurs due to chronic Amiodarone therapy.
How does it look like?
Slate gray hyperpigmentation of frontal cheeks, sometimes also of the nail bed of the back of the hand.
Why blue man syndrome occurs?
A. Deposition of Lipofuscin in macrophages in dermis.
B. Drug-induced phospholipidosis-accumulation of drug-lipid complexes in lysosomes.
What is the treatment?
Stopping amiodarone therapy may reverse the skin color changes.