What is the differential diagnosis of eosinophilic granulomatosis with polyangiitis ?

The differential diagnosis is:

• Granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA)
• Polyarteritis nodosa (PAN)
• Allergic bronchopulmonary aspergillosis (ABPA)
• Chronic eosinophilic pneumonia (CEP)
• Hypereosinophilic syndrome (HES)
• Rheumatoid arthritis
  EGPA can be distinguished from the above diagnoses by the following:
• In contrast to the other ANCA-associated vasculitides, including MPA and GPA, EGPA is associated with asthma and eosinophilia.
• Kidney involvement and pulmonary nodule cavitation are much less common in EGPA compared to GPA.
• PAN is a medium-vessel vasculitis, and unlike EGPA, it does not involve the lung.
• CEP and ABPA are limited to lung involvement.
• ANCAs, asthma, and vasculitis are not features of HES, in contrast to EGPA.