LMWH and vitamin K antagonists are widely accepted and used to treat primary thrombosis of the portal venous system or hepatic venous outflow tract.
There are no major concerns regarding the safety of DOACs in patients with non-cirrhotic vascular liver diseases, as long as liver function is preserved. DOACs should be used with caution in patients with impaired liver function (equivalent to Child-Pugh class B), as well as in patients with creatinine clearance below 30 ml/min. The use of DOACs in patients with severe liver dysfunction (equivalent to Child-Pugh C) is not recommended outside study protocols.
Corrigendum to ‘Baveno VII – Renewing consensus in portal hypertension’ [J Hepatol (2022) 959-974] Journal of Hepatology, Vol. 77, Issue 2